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Copy number variation profile in the placental and parental genomes of recurrent pregnancy loss families. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Ehret, Georg B. Laan, M.

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Johnson, T. Wang, Xiaoling; Prins, Bram P. Sõber, S. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Wain, L. Metspalu, A. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.

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Age-dependent association of the polymorphisms in the mitochondria-shaping gene, OPA1, with blood pressure and hypertension in Korean population. Fox, E. Newton-Cheh, C. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Dissertatsioonide seerias ilmunud dissertatsioonid v.

Hypervariable intronic region in NCX1 is enriched in short insertion-deletion polymorphisms and showed association with cardiovascular traits. Laan, M. Targeting candidate genes for blood pressure regulation with a genome-wide genotyping array.

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Genome-wide association study for blood pressure traits. We determined here whether these impairments are associated with changes in general levels of activity, anxiety or 'depressive-like' symptomatology due to chronic oestrogen deficiency. We also compared the neurochemical profile of ArKO and wild-type WT females, as oestrogens have been shown to modulate dopaminergic, serotonergic and noradrenergic brain activities.

Dalla, C; Antoniou, K; Papadopoulou-Daifoti, Z; Balthazart, J; Bakker, J We recently found that female aromatase knockout ArKO mice that are deficient in oestradiol due to a targeted mutation in the aromatase gene show deficits in sexual behaviour that cannot be corrected by adult treatment with oestrogens.

ArKO females did not differ from WT in spontaneous motor activity, exploration or anxiety. These findings are in line with the absence of major neurochemical alterations in hypothalamus, prefrontal cortex or striatum, which are involved in the expression of these behaviours.

By contrast, ArKO females displayed decreased active behaviours, such as struggling and swimming, and increased passive behaviours, such as floating, in repeated sessions of the forced swim test, indicating that these females exhibit 'depressive-like' symptoms.

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Adult treatment with oestradiol did not reverse the behavioural deficits observed in the forced swim test, suggesting that they may be due to the absence of oestradiol during development. Accordingly, an increased serotonergic activity was observed in the hippocampus of ArKO females compared with WT, which was also not reversed by adult oestradiol treatment.

The possible organizational role of oestradiol on the hippocampal serotonergic system and the 'depressive-like' profile of ArKO females provide new insights into the pathophysiology of depression and the increased vulnerability of women to depression.

Konverentsiteesid, mida kajastab Thomson Reuters Web of Science 1. Lühikirjutised teadusajakirjades ja kogumikes 1. Effects of RNA integrity on transcript quantification by total RNA sequencing of clinically collected human placental samples. DOI: Copy number variation profile in the placental and parental genomes of recurrent pregnancy loss families.

Directory of Open Access Journals Sweden Jingbo Pang Full Text Available Obesity and type 2 diabetes are associated with increased production of Galectin-3 Gal-3, a protein that modulates inflammation and clearance of glucose adducts. Deficiency of Gal-3 lead to age-dependent development of excess adiposity and systemic inflammation, as indicated by elevated production of acute-phase proteins, number of circulating pro-inflammatory Ly6C high monocytes and development of neutrophilia, microcytic anemia and thrombocytosis in week-old Lean and DIO male Gal-3 KO mice.

This was associated with impaired fasting glucose, heightened response to a glucose tolerance test and reduced adipose tissue expression of adiponectin, Gal, ATGL and PPARγ, in the presence of maintained insulin sensitivity and hepatic expression of gluconeogenic enzymes in week-old Gal-3 KO mice compared to their diet-matched WT controls.

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